High-resolution reference ranges for estradiol, luteinizing hormone, and follicle-stimulating hormone in men and women using the AxSYM assay system.

OBJECTIVES High-resolution reference ranges are essential for reproductive hormones due to the significant day-to-day variation seen with these analytes. DESIGN AND METHODS The performance of AxSYM assays for estradiol, luteinizing hormone (LH), and follicle-stimulating hormone was evaluated. RESULTS These studies validate the performance of each assay, permitting high-resolution reference ranges to be established. CONCLUSIONS The high-resolution reference range data provided herein for both normally cycling females and males should be applicable to a wide variety of clinical situations.